High-affinity antagonists of the locust neuronal octopamine receptor.

  title={High-affinity antagonists of the locust neuronal octopamine receptor.},
  author={Thomas Roeder},
  journal={European journal of pharmacology},
  volume={191 2},
  • T. Roeder
  • Published 27 November 1990
  • Biology
  • European journal of pharmacology
Pharmacology of the octopamine receptor from locust central nervous tissue (OAR3)
  • T. Roeder
  • Biology, Chemistry
    British journal of pharmacology
  • 1995
A variety of substances with known insecticidal activity such as chlordime form, demethylchlor‐dimeform, amitraz or AC 6 had high affinity for the locust neuronal octopamine receptor.
Octopaminergic agonists for the cockroach neuronal octopamine receptor
Two compounds showed the almost same activity as octopamine in stimulating adenylate cyclase of cockroach thoracic nervous system among 70Octopamine agonists, suggesting that only these compounds are full octopamines agonists and other compounds are partial octopaminergic agonists.
Neurotransmitter-receptors as targets for new insecticides
Using structure-activity relationships, a number of high affinity agonists of this receptor subtype are characterized and a variety of these compounds show a high degree of specificity for insect octopamine receptors versus vertebrate adrenergic receptors.
Octopamine receptor subtypes and their modes of action
The current status of this classification is reviewed by examining the pharmacology of responses to octopamine in a range of preparations and it is concluded that the distinction between OCTOPAMINE1 and OCTopAMINE2 receptor types is still valid, but that OCTOPamINE2 receptors exhibit some tissue specific variations.
Photoaffinity Labeling of a Neuronal Octopamine Receptor
Abstract: The invertebrate aminergic neurotransmitter and neuromodulator octopamine (OA) acts at both neuronal and nonneuronal receptors that appear to have distinct pharmacological characteristics.
Quantitative Structure-Activity Studies of Octopaminergic Agonists and Antagonists Against Locusta migratoria Using Similarity Indexes
For OA agonists, the more similar to reference compound NC (24) the structure of test compound, the higher the activity, whereas for OA antagonists it was not the case.


Octopamine receptors in locust nervous tissue.
Multiple receptor types for octopamine in the locust.
  • P. Evans
  • Biology
    The Journal of physiology
  • 1981
The results are discussed in terms of the location of the various classes of octopamine receptors, their possible relationship to vertebrate alpha‐adrenoreceptors, and the significance of the results for studies on octopamines receptors in the vertebrate central nervous system.
Phenyliminoimidazolidines. Characterization of a class of potent agonists of octopamine-sensitive adenylate cyclase and their use in understanding the pharmacology of octopamine receptors.
Comparison of the relative binding affinities of various PIIs for mammalian alpha-adrenergic receptors, as well as the ability of various antagonists to block PII binding, strongly suggested that the active PIIs are affecting a class of octopamine receptors distinct from mammalian alpha 1- or alpha 2-adRenergic receptors.
Octopamine in insects: neurotransmitter, neurohormone, and neuromodulator
It is shown that octopamine can act as a neurotransmitter, a neurohormone, and a neuromodulator within the nervous system of invertebrates and in locusts, an identified octopaminergic neuron innervates the extensor-tibiae muscle of the hind legs.
Generation of specific behaviors in a locust by local release into neuropil of the natural neuromodulator octopamine.
A hypothesis, termed the Orchestration Hypothesis is presented, which considers how modulator neurons such as locust octopaminergic neurons, might be involved in the generation of specific behaviors.