High affinity aldosterone binding sites (type I receptors) in rat heart.

@article{Pearce1987HighAA,
  title={High affinity aldosterone binding sites (type I receptors) in rat heart.},
  author={Philippa Pearce and John W. Funder},
  journal={Clinical and experimental pharmacology & physiology},
  year={1987},
  volume={14 11-12},
  pages={
          859-66
        }
}
1. The use of the receptor stabilizing agent sodium molybdate, and of RU26988 to exclude [3H]-aldosterone binding from Type II glucocorticoid receptors, has enabled the characterization of high affinity Type I aldosterone binding sites in rat atrial and ventricular cytosols. 2. In adult male and female rats the affinity of binding (Kd 4 degrees C) is approximately 1-2 nmol/l for both atria and ventricles; specificity of binding is similar to that for Type I sites in classical aldosterone target… CONTINUE READING
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