High affinity T cell receptors from yeast display libraries block T cell activation by superantigens.

@article{Kieke2001HighAT,
  title={High affinity T cell receptors from yeast display libraries block T cell activation by superantigens.},
  author={Michele C. Kieke and Eric Sundberg and Eric V Shusta and Roy A. Mariuzza and K Dane Wittrup and David M. Kranz},
  journal={Journal of molecular biology},
  year={2001},
  volume={307 5},
  pages={1305-15}
}
The alphabeta T cell receptor (TCR) can be triggered by a class of ligands called superantigens. Enterotoxins secreted by bacteria act as superantigens by simultaneously binding to an MHC class II molecule on an antigen- presenting cell and to a TCR beta-chain, thereby causing activation of the T cell. The cross-reactivity of enterotoxins with different Vbeta regions can lead to stimulation of a large fraction of T cells. To understand the molecular details of TCR-enterotoxin interactions and… CONTINUE READING

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