High-affinity IgE receptor on eosinophils is involved in defence against parasites

@article{Gounni1994HighaffinityIR,
  title={High-affinity IgE receptor on eosinophils is involved in defence against parasites},
  author={Abdelillah Soussi Gounni and Bouchaib Lamkhioued and Kenichi Ochiai and Yoichi Tanaka and Emmanuel Delaporte and Andr{\'e} Capron and Jean Pierre Kinet and M. Capron},
  journal={Nature},
  year={1994},
  volume={367},
  pages={183-186}
}
PARASITIC infections are often associated with eosinophilia and high levels of immunoglobulin E (IgE). This observation has led to speculation that eosinophils and IgE may act together in the immune response against parasites. In support of this hypothesis, IgE and eosinophils participate in cytotoxic reactions directed against Schistosoma mansoni larvae in vitro 1,2. Furthermore, epidemiological studies have shown an inverse correlation between levels of specific IgE and rates of infection… 
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A novel view of neutrophils as possible source of ECP in IgE-dependent diseases is presented.
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