High-affinity CCK receptors are coupled to phospholipase A2 pathways to mediate pancreatic amylase secretion.

@article{Tsunoda1995HighaffinityCR,
  title={High-affinity CCK receptors are coupled to phospholipase A2 pathways to mediate pancreatic amylase secretion.},
  author={Yasuhiro Tsunoda and Chung Owyang},
  journal={The American journal of physiology},
  year={1995},
  volume={269 3 Pt 1},
  pages={G435-44}
}
It is well recognized that JMV-180, a cholecystokinin (CCK) analogue, acts as an agonist on the high-affinity CCK receptor in pancreatic acinar cells. It caused Ca2+ oscillations and amylase secretion in a manner independent of the phospholipase C-inositol 1,4,5-trisphosphate (IP3) pathway. We investigated the mechanism by which the high-affinity CCK receptor utilizes IP3-independent Ca2+ signal transduction to mediate amylase secretion. JMV-180 (1-1,000 nM)-stimulated Ca2+ oscillations and… CONTINUE READING

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