High-affinity B cell receptor ligation by cognate antigen induces cytokine-independent isotype switching.


The selection of an appropriate Ig isotype is critical for an effective immune response against pathogens. Isotype regulation is sensitive to external signals, particularly cytokines secreted by Th cells. For example, IL-4 induces isotype switching to IgG1 via a STAT6-dependent signaling pathway. In this study, we show that BCR ligation also induces IgG1… (More)
DOI: 10.4049/jimmunol.0903437


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