High affinity, dsRNA binding by disconnected interacting protein 1.

@article{Catanese2010HighAD,
  title={High affinity, dsRNA binding by disconnected interacting protein 1.},
  author={Daniel James Catanese and Kathleen Shive Matthews},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={399 2},
  pages={
          186-91
        }
}
Disconnected interacting protein 1 (DIP1) appears from sequence analysis and preliminary binding studies to be a member of the dsRNA-binding protein family. Of interest, DIP1 was shown previously to interact with and influence multiple proteins involved in transcription regulation in Drosophila melanogaster. We show here that the longest isoform of this protein, DIP1-c, exhibits a 500-fold preference for dsRNA over dsDNA of similar nucleotide sequence. Further, DIP1-c demonstrated very high… CONTINUE READING
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