High-activity variants of the uMAOA polymorphism increase the risk for depression in a large primary care sample.

@article{Rivera2009HighactivityVO,
  title={High-activity variants of the uMAOA polymorphism increase the risk for depression in a large primary care sample.},
  author={Margarita Rivera and Blanca L Guti{\'e}rrez and Esther Molina and Francisco Torres-Gonz{\'a}lez and Juan {\'A}ngel Bell{\'o}n and Berta Moreno-K{\"u}stner and Michael King and Irwin Nazareth and Luis Javier Martinez-Gonzalez and Esther Mart{\'i}nez-Esp{\'i}n and Mar{\'i}a del Mar Mu{\~n}oz-Garc{\'i}a and Emma Motrico and Teresa Mart{\'i}nez-Ca{\~n}avate and Jose Antonio Lorente and Juan de Dios Luna and Jorge Cervilla},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2009},
  volume={150B 3},
  pages={395-402}
}
Studies on the association between the functional uMAOA polymorphism and depression have yielded non-conclusive results up till now. One thousand two hundred twenty eight consecutive Spanish primary care attendees, participating in the PREDICT study, agreed to take part in this genetic PREDICT-Gene study. We explored the association between depression and either high-activity uMAOA alleles or genotypes. Depression was diagnosed using the Composite International Diagnostic Interview (CIDI) to… CONTINUE READING

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