High activity-related allele of MAO-A gene associated with depressed suicide in males

  title={High activity-related allele of MAO-A gene associated with depressed suicide in males},
  author={Lisheng Du and G{\'a}bor Faludi and Mikl{\'o}s Palkovits and P{\'e}ter S{\'o}tonyi and David Bakish and Pavel D. Hrdina},
Abnormalities in brain monoamine oxidase A activity have been implicated in the pathogenesis of depressive illness and suicidal behavior. The present investigation was to determine whether there is an association between MAO-A gene polymorphism and depressed suicide. The Eco RV polymorphism in MAO-A gene with alleles associated with enzyme activity was studied in postmortem brain samples from 44 depressed suicide victims and 92 control subjects of the same ethnic background. We have found… 

An Association between a Functional Polymorphism in the Monoamine Oxidase A Gene Promoter, Impulsive Traits and Early Abuse Experiences

The results suggest that the lower expression of the MAOA-uVNTR polymorphism is related to a history of early Abuse and may sensitize males, but not females, to the effects of early abuse experiences on impulsive traits in adulthood.

Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder

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The monoamine oxidase A gene may influence the means used in suicide attempts

An excess of high-activity monoamine oxidase A gene promoter alleles may be associated with traits orienting suicidal behavior towards a violent act.

MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males

The data suggest that the EcoRV and uVNTR polymorphisms may be involved in the pathogenesis of major depression and associated with insomnia in depressed patients.

Association and Interaction of the MAOA Promoter uVNTR Polymorphism with Suicide Attempts in Patients with Major Depressive Disorder

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Monoamino Oxidase A Gene Single-Nucleotide Polymorphisms and Methylation Status and the Risk of Violent Suicide Attempts in Affective Disorder Patients

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Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder.

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Additional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorder.

The MAO-A/EcoRV polymorphism was reexamined in a sample of 122 OCD patients and 124 healthy subjects to provide molecular evidence to identify a clinically meaningful gender subtype and suggest the possibility of gender differences in genetic susceptibility for OCD.

Serotonergic genes and suicidality.

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Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders.

There is no association between MAOA-LPR genotype and susceptibility to recurrent major depression, bipolar disorder, and schizophrenia in the population of patients tested.

A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder.

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Pathological gambling and DNA polymorphic markers at MAO-A and MAO-B genes

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Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study.

A candidate gene association approach was applied to study the involvement of the monoamine oxidase A (MAOA) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder.

Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder.

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