High activity-related allele of MAO-A gene associated with depressed suicide in males

@article{Du2002HighAA,
  title={High activity-related allele of MAO-A gene associated with depressed suicide in males},
  author={Lisheng Du and G{\'a}bor Faludi and Mikl{\'o}s Palkovits and P{\'e}ter S{\'o}tonyi and David Bakish and Pavel D. Hrdina},
  journal={Neuroreport},
  year={2002},
  volume={13},
  pages={1195-1198}
}
Abnormalities in brain monoamine oxidase A activity have been implicated in the pathogenesis of depressive illness and suicidal behavior. The present investigation was to determine whether there is an association between MAO-A gene polymorphism and depressed suicide. The Eco RV polymorphism in MAO-A gene with alleles associated with enzyme activity was studied in postmortem brain samples from 44 depressed suicide victims and 92 control subjects of the same ethnic background. We have found… 

An Association between a Functional Polymorphism in the Monoamine Oxidase A Gene Promoter, Impulsive Traits and Early Abuse Experiences

The results suggest that the lower expression of the MAOA-uVNTR polymorphism is related to a history of early Abuse and may sensitize males, but not females, to the effects of early abuse experiences on impulsive traits in adulthood.

Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder

The MAOA 4R allele is associated with enhanced vulnerability to suicide in depressed males, but not in community subjects, and nongenetic factors, such as age, paternal overprotection, and somatic symptoms, were associated with MDD, whereas depressed suicide wereassociated with severity of depression, personality traits, age, marital status, and inversely associated with anxiety symptoms.

The monoamine oxidase A gene may influence the means used in suicide attempts

An excess of high-activity monoamine oxidase A gene promoter alleles may be associated with traits orienting suicidal behavior towards a violent act.

MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males

The data suggest that the EcoRV and uVNTR polymorphisms may be involved in the pathogenesis of major depression and associated with insomnia in depressed patients.

Association and Interaction of the MAOA Promoter uVNTR Polymorphism with Suicide Attempts in Patients with Major Depressive Disorder

The MAOA long-form variant was associated with enhanced vulnerability to suicide in the general population and neuroticism, extraversion, low levels of anxiety, high levels of depressive symptoms, and smoking were associated with suicidal behavior in MDD group, not in the group of subjects without MDD.

Monoamino Oxidase A Gene Single-Nucleotide Polymorphisms and Methylation Status and the Risk of Violent Suicide Attempts in Affective Disorder Patients

Female affective disorder patients with a history of violent suicide attempt were found to have a significantly increased frequency of the AA genotype in the rs5906957 single nucleotide polymorphism, and the MAOA gene exon I promoter region showed significantly decreased methylation in female violent suicide attempter(s).

Neither single-marker nor haplotype analyses support an association between monoamine oxidase A gene and bipolar disorder

The results suggest that MAOA polymorphisms do not play a major role in pathogenesis of BD or its clinical subtypes in Han Chinese and are not associated with BD or any of its subtypes, in either the frequencies of alleles or genotypes.
...

References

SHOWING 1-10 OF 23 REFERENCES

Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder.

It is suggested that an excess of high-activity MAO-A gene promoter alleles resulting in an elevated MAo-A activity is a risk factor for major depressive disorder in females.

Additional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorder.

The MAO-A/EcoRV polymorphism was reexamined in a sample of 122 OCD patients and 124 healthy subjects to provide molecular evidence to identify a clinically meaningful gender subtype and suggest the possibility of gender differences in genetic susceptibility for OCD.

Serotonergic genes and suicidality.

The results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression and not with depression itself, and supports the hypothesis that genetic factors can modulate suicide risk by influencing serotonergic activity.

Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders.

There is no association between MAOA-LPR genotype and susceptibility to recurrent major depression, bipolar disorder, and schizophrenia in the population of patients tested.

A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder.

It is found that none of the different repeat copies was preferentially transmitted from mothers to their children affected with bipolar disorder and a non-significant trend for patients with an ultra-rapid cycling form of illness to have a higher frequency of low-activity alleles is found.

Pathological gambling and DNA polymorphic markers at MAO-A and MAO-B genes

Allele variants at the MAOA, but not the MAOB gene may be a genetic liability factor in PG, at least in severe male gamblers.

Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study.

A candidate gene association approach was applied to study the involvement of the monoamine oxidase A (MAOA) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder.

Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder.

The associations with the MAOA and serotonin transporter loci are consistent with previous data suggesting associations with susceptibility to bipolar affective disorder and type 1 errors are possible.