High-abundance mRNAs in human muscle: comparison between young and old.

@article{Welle2000HighabundanceMI,
  title={High-abundance mRNAs in human muscle: comparison between young and old.},
  author={Stephen Welle and Kirti Bhatt and Charles A. Thornton},
  journal={Journal of applied physiology},
  year={2000},
  volume={89 1},
  pages={
          297-304
        }
}
To gain a better understanding of the potential role of altered gene expression in the diminished muscle function in old age, we performed a broad search for transcripts expressed at quantitatively different levels in younger (21-24 yr) and older (66-77 yr) human vastus lateralis muscle by serial analysis of gene expression (SAGE). Because SAGE was based on RNA pooled from muscle of several different subjects, relative concentrations of selected mRNAs also were determined in individual muscle… CONTINUE READING
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