High WT1 expression after induction therapy predicts high risk of relapse and death in pediatric acute myeloid leukemia.

@article{Lapillonne2006HighWE,
  title={High WT1 expression after induction therapy predicts high risk of relapse and death in pediatric acute myeloid leukemia.},
  author={H{\'e}l{\`e}ne Lapillonne and Aline Renneville and Anne Auvrignon and Cyril Flamant and Annick Blaise and Christine P{\'e}rot and Jean-Luc Lai and Paola Ballerini and Françoise Mazingue and Sylvie Fasola and Axelle Deh{\'e}e and Françoise Bellman and Mirc{\'e}a Adam and Myriam Labopin and Luc Douay and Guy Leverger and Claude Preudhomme and Judith Landman-Parker},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 10},
  pages={
          1507-15
        }
}
PURPOSE To determine whether minimal residual disease (MRD) measured by Wilms' tumor gene 1 (WT1) expression is a prognostic marker in pediatric acute myeloid leukemia (AML), we quantified WT1 transcript by real-time quantitative-polymerase chain reaction in 92 AML at diagnosis and during follow-up. PATIENTS AND METHODS Patients (median age, 6 years; cytogenetics, favorable 27%, intermediate 59%, poor 13%) were treated between 1995 and 2002 and enrolled in Leucémie aiguë Myéloblastique Enfant… CONTINUE READING

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