High Variability of Hormonal Levels and No Clinically Relevant Interaction Between Ethinyl Estradiol, Desogestrel and Lopinavir/Ritonavir in a Small Sample of HIV-positive Adolescents.

@article{Landolt2016HighVO,
  title={High Variability of Hormonal Levels and No Clinically Relevant Interaction Between Ethinyl Estradiol, Desogestrel and Lopinavir/Ritonavir in a Small Sample of HIV-positive Adolescents.},
  author={Nadia Kancheva Landolt and Torsak Bunupuradah and Pope Kosalaraksa and Sasiwimol Ubolyam and Narukjaporn Thammajaruk and Serge Cremers and Roseann Zott and Stephen Kerr and Jintanat Ananworanich},
  journal={Journal of acquired immune deficiency syndromes},
  year={2016},
  volume={72 5},
  pages={
          507-12
        }
}
BACKGROUND We report the pharmacokinetic interactions of combined oral contraceptive (COC) containing ethinyl estradiol (EE2)/desogestrel (DSG) with lopinavir/ritonavir (LPV/r) in 16 HIV-positive adolescents. METHODS We measured Ctrough of EE2 and etonogestrel (ENG), the active metabolite of DSG, in HIV-positives on LPV/r-based ART; Ctrough of LPV/r with and without COC; endogenous progesterone. EE2/ENG levels were compared with our own historical data of HIV-negative controls. RESULTS… CONTINUE READING
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