High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model

@inproceedings{Kong2015HighTS,
  title={High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model},
  author={Yan Kong and Xijun Liang and Lin Liu and Dongdong Zhang and C. L. Johnny Wan and Zhenji Gan and Liudi Yuan and Bing-Hua Jiang},
  booktitle={PloS one},
  year={2015}
}
Parkinson's disease (PD) is a prevalent neurodegenerative disorder with pathological features including death of dopaminergic neurons in the substantia nigra and intraneuronal accumulations of Lewy bodies. As the main component of Lewy bodies, α-synuclein is implicated in PD pathogenesis by aggregation into insoluble filaments. However, the detailed… CONTINUE READING