High-Throughput Screening and Rapid Inhibitor Triage Using an Infectious Chimeric Hepatitis C Virus

  title={High-Throughput Screening and Rapid Inhibitor Triage Using an Infectious Chimeric Hepatitis C Virus},
  author={Michael J. Wichroski and Jie Fang and Betsy J. Eggers and Ronald E. Rose and Charles E. Mazzucco and Kevin A. Pokornowski and Carl J. Baldick and Monique Nicole Anthony and Craig J. Dowling and Lauren Barber and John E. Leet and Brett R. Beno and Samuel W. Gerritz and Michele L. Agler and Mark I. Cockett and Daniel J Tenney},
  booktitle={PloS one},
The recent development of a Hepatitis C virus (HCV) infectious virus cell culture model system has facilitated the development of whole-virus screening assays which can be used to interrogate the entire virus life cycle. Here, we describe the development of an HCV growth assay capable of identifying inhibitors against all stages of the virus life cycle with assay throughput suitable for rapid screening of large-scale chemical libraries. Novel features include, 1) the use of an efficiently… CONTINUE READING
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