High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni

@inproceedings{Mansour2016HighTS,
  title={High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni},
  author={Nuha R N Mansour and Ross A. Paveley and J. Mark F. Gardner and Andrew S Bell and Tanya Parkinson and Quentin Bickle},
  booktitle={PLoS neglected tropical diseases},
  year={2016}
}
An estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one drug recommended for treating schistosomiasis, praziquantel (PZQ), which is effective against adult worms but not against the juvenile stage. In an attempt to identify improved drugs for treating the disease, we have carried out high throughput screening of a number of small molecule libraries with the aim of identifying lead compounds… CONTINUE READING
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