High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays.

Abstract

GluK1, a kainate subtype of ionotropic glutamate receptors, exhibits an expression pattern in the CNS consistent with involvement in pain processing and migraine. Antagonists of GluK1 have been shown to reduce pain signaling in the spinal cord and trigeminal nerve, and are predicted to provide pain and migraine relief. We developed an ultra-high-throughput… (More)
DOI: 10.1177/1087057115570580

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Cite this paper

@article{Solly2015HighThroughputSO, title={High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays.}, author={Kelli J Solly and Rebecca Klein and Michael T. Rudd and M. Katharine Holloway and Eric N. Johnson and Darrell A. Henze and Michael Finley}, journal={Journal of biomolecular screening}, year={2015}, volume={20 6}, pages={708-19} }