High-Throughput Quantification of Surface Protein Internalization and Degradation.

  title={High-Throughput Quantification of Surface Protein Internalization and Degradation.},
  author={Jakob C St{\"u}ber and Florian Kast and A. Pl{\"u}ckthun},
  journal={ACS chemical biology},
  • Jakob C Stüber, Florian Kast, A. Plückthun
  • Published 2019
  • Medicine
  • ACS chemical biology
  • Cell surface proteins are key regulators of fundamental cellular processes and, therefore, often at the root of human diseases. Thus, a large number of targeted drugs which are approved or under development act upon cell surface proteins. Although down-regulation of surface proteins by many natural ligands is well-established, the ability of drug candidates to cause internalization or degradation of the target is only recently moving into focus. This property is important both for the… CONTINUE READING
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