High-Throughput Molecular Imaging for the Identification of FADD Kinase Inhibitors

@article{Khan2010HighThroughputMI,
  title={High-Throughput Molecular Imaging for the Identification of FADD Kinase Inhibitors},
  author={Amjad P. Khan and Katrina A. Schinske and Shyam Nyati and Mahaveer Swaroop Bhojani and Brian D. Ross and Alnawaz Rehemtulla},
  journal={Journal of Biomolecular Screening},
  year={2010},
  volume={15},
  pages={1063 - 1070}
}
Fas-associated protein with death domain (FADD) was originally reported as a proapoptotic adaptor molecule that mediates receptor-induced apoptosis. Recent studies have revealed a potential role of FADD in NF-κB activation, embryogenesis, and cell cycle regulation and proliferation. Overexpression of FADD and its phosphorylation have been associated with the transformed phenotype in many cancers and is therefore a potential target for therapeutic intervention. In an effort to delineate… Expand
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