High-Throughput Microfluidic Platform for 3D Cultures of Mesenchymal Stem Cells, Towards Engineering Developmental Processes

@inproceedings{Occhetta2015HighThroughputMP,
  title={High-Throughput Microfluidic Platform for 3D Cultures of Mesenchymal Stem Cells, Towards Engineering Developmental Processes},
  author={Paola Occhetta and Matteo Centola and Beatrice Tonnarelli and Alberto Redaelli and Ivan Martin and Marco Rasponi},
  booktitle={Scientific reports},
  year={2015}
}
The development of in vitro models to screen the effect of different concentrations, combinations and temporal sequences of morpho-regulatory factors on stem/progenitor cells is crucial to investigate and possibly recapitulate developmental processes with adult cells. Here, we designed and validated a microfluidic platform to (i) allow cellular condensation, (ii) culture 3D micromasses of human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) under continuous flow perfusion, and (ii… CONTINUE READING
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Recent Developments in Microfluidics for Cell Studies

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