High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

@inproceedings{Hirota2010HighThroughputCS,
  title={High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase},
  author={Tsuyoshi Hirota and Jae Wook Lee and Warren Lewis and Eric Erquan Zhang and Ghislain Breton and Xianzhong Liu and M. Concepcion Garcia and Eric C. Peters and J Etchegaray and David Traver and Peter G. Schultz and Steve A Kay},
  booktitle={PLoS biology},
  year={2010}
}
The circadian clock underlies daily rhythms of diverse physiological processes, and alterations in clock function have been linked to numerous pathologies. To apply chemical biology methods to modulate and dissect the clock mechanism with new chemical probes, we performed a circadian screen of ∼120,000 uncharacterized compounds on human cells containing a circadian reporter. The analysis identified a small molecule that potently lengthens the circadian period in a dose-dependent manner… CONTINUE READING

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