High-Throughput Biophysical Analysis of Protein Therapeutics to Examine Interrelationships Between Aggregate Formation and Conformational Stability

@article{Chaudhuri2013HighThroughputBA,
  title={High-Throughput Biophysical Analysis of Protein Therapeutics to Examine Interrelationships Between Aggregate Formation and Conformational Stability},
  author={Rajoshi Chaudhuri and Yuan Bing Cheng and C. Russell Middaugh and David B. Volkin},
  journal={The AAPS Journal},
  year={2013},
  volume={16},
  pages={48-64}
}
  • Rajoshi Chaudhuri, Yuan Bing Cheng, +1 author David B. Volkin
  • Published in The AAPS Journal 2013
  • Medicine, Chemistry
  • Stabilization and formulation of therapeutic proteins against physical instability, both structural alterations and aggregation, is particularly challenging not only due to each protein’s unique physicochemical characteristics but also their susceptibility to the surrounding milieu (pH, ionic strength, excipients, etc.) as well as various environmental stresses (temperature, agitation, lyophilization, etc.). The use of high-throughput techniques can significantly aid in the evaluation of… CONTINUE READING

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