High Susceptibility of p 53 ( + / †” ) Knockout Mice in W-Butyl-W-( 4-hydroxybutyl ) nitrosamine Urinary Bladder Carcinogenesis and Lack of Frequent Mutation in Residual AlÃ-ele 1


I litloss of /o.< functions is considered to compromise the growthsuppression machinery of the cell and facilitate neoplastic change. In humans, genetic alteration in the p53 gene is one of the most frequently observed molecular changes in tumors, including urinary bladder carci nomas. We have investigated the susceptibility of heterozygotep5J knock out… (More)

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