High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosis.

@article{IsakssonMettvainio2012HighSL,
  title={High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosis.},
  author={Martin Isaksson-Mett{\"a}vainio and Richard Palmqvist and Anna M. Dahlin and Bethany van Guelpen and J{\"o}rgen N. Ruteg{\aa}rd and Ake Oberg and Maria L. Henriksson},
  journal={International journal of cancer},
  year={2012},
  volume={131 4},
  pages={779-88}
}
Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths in western countries. CRC are commonly divided in cancers showing microsatellite stability (MSS) or microsatellite instability (MSI). A more novel classification is dependent on promoter hypermethylation of CpG islands (the CpG island methylator phenotype, CIMP), where cancers show high, low or negative methylation status. SMAD4, located on chromosome 18q, has been thoroughly investigated during the last years… CONTINUE READING

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