High Risk of Severe Anaemia after Chlorproguanil-Dapsone+Artesunate Antimalarial Treatment in Patients with G6PD (A-) Deficiency

@article{Fanello2008HighRO,
  title={High Risk of Severe Anaemia after Chlorproguanil-Dapsone+Artesunate Antimalarial Treatment in Patients with G6PD (A-) Deficiency},
  author={Caterina I. Fanello and Corine Karema and Pamela Avellino and Germana Bancone and Aline Uwimana and Sue J Lee and Umberto D'Alessandro and David Laurence Modiano},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={412 - 420}
}
BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited human enzyme defect. This deficiency provides some protection from clinical malaria, but it can also cause haemolysis after administration of drugs with oxidant properties. METHODS The safety of chlorproguanil-dapsone+artesunate (CD+A) and amodiaquine+sulphadoxine… CONTINUE READING