High-Resolution Recombination Patterns in a Region of Human Chromosome 21 Measured by Sperm Typing

@article{TiemannBoege2005HighResolutionRP,
  title={High-Resolution Recombination Patterns in a Region of Human Chromosome 21 Measured by Sperm Typing},
  author={Irene Tiemann-Boege and Peter P. Calabrese and David M. Cochran and Rebecca Z. Sokol and Norman Arnheim},
  journal={PLoS Genetics},
  year={2005},
  volume={2},
  pages={413 - 424}
}
For decades, classical crossover studies and linkage disequilibrium (LD) analysis of genomic regions suggested that human meiotic crossovers may not be randomly distributed along chromosomes but are focused instead in "hot spots." Recent sperm typing studies provided data at very high resolution and accuracy that defined the physical limits of a number of hot spots. The data were also used to test whether patterns of LD can predict hot spot locations. These sperm typing studies focused on… CONTINUE READING

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