High-Resolution Profiling of Histone Methylations in the Human Genome

@article{Barski2007HighResolutionPO,
  title={High-Resolution Profiling of Histone Methylations in the Human Genome},
  author={Artem Barski and Suresh Cuddapah and Kairong Cui and Tae-Young Roh and Dustin E. Schones and Zhibin Wang and Gang Wei and Iouri Chepelev and Keji Zhao},
  journal={Cell},
  year={2007},
  volume={129},
  pages={823-837}
}

Figures and Tables from this paper

Characterization of Chromatin Structure-associated Histone Modifications in Breast Cancer Cells

TLDR
The results might provide an insight into epigenetic regulatory mechanisms explaining the association of histone modifications with open chromatin structure in breast cancer cells, and functional sequence motifs at H3K4me1-enriched FAIRE sites upstream of putative promoters are identified, suggesting that regulatory elements could be associated with H 3K 4me1 to be regarded as distal regulatory elements.

Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression

TLDR
The results suggest that H 4K16 acetylation has a limited effect on transcription regulation in HEK293 cells, whereas H4K16ac has been demonstrated to have critical roles in regulating transcription in mouse embryonic stem cells.

Deposition of Histone Variant H2A.Z within Gene Bodies Regulates Responsive Genes

TLDR
It is proposed that H2A.Z deposition in gene bodies promotes variability in levels and patterns of gene expression, and that a major function of genic DNA methylation is to exclude H2a.Z from constitutively expressed genes.

Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences

TLDR
The dynamic H3 acetylations define P. falciparum regulatory sequences and contribute to gene activation as well as expanding the knowledge of the chromatin landscape that regulates gene expression in the malaria parasite.

Genome-Wide Profiling of Histone H3 Lysine 4 and Lysine 27 Trimethylation Reveals an Epigenetic Signature in Prostate Carcinogenesis

TLDR
The data indicate an H3K4me3/H3K27me3 epigenetic signature of prostate carcinogenesis, which contributes to an overall understanding of coordinated regulation of gene expression in cancer.

Histone H1 binding is inhibited by histone variant H3.3

TLDR
A genome‐wide high‐resolution binding map for linker histone H1 in Drosophila cells is generated, showing that the H3.3 protein counteracts association of H1, providing a mechanism to keep diverse genomic sites in an open chromatin conformation.

Genome-wide profiling of histone H3 lysine 9 acetylation and dimethylation in Arabidopsis reveals correlation between multiple histone marks and gene expression

TLDR
A significant increase of the H3K9ac modification level of selected target genes in hda19 (histone deacetylase 19) mutant seedlings was observed, which indicated that HDA19 plays an important role in regulating the level of H3k9ac and thereby influencing the transcriptional activity in young seedlings.
...

References

SHOWING 1-10 OF 63 REFERENCES

Profile of Histone Lysine Methylation across Transcribed Mammalian Chromatin

TLDR
A comparative assessment of all six known positions of histone lysine methylation indicates that H4K20 and H3K27 monomethylation are versatile and dynamic with respect to gene activity, suggesting the existence of novel site-specific methyltransferases and demethylases coupled to the transcription cycle.

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

TLDR
Insight is given into the connections between chromatin modifications and transcriptional regulatory activity and a novel functional enhancer for the carnitine transporter SLC22A5 (OCTN2) is uncovered, providing a new tool for the functional annotation of the human genome.

The genomic landscape of histone modifications in human T cells

TLDR
Investigation of the genomic landscape of activating histone modifications in primary human T cells reveals that rapidly inducible genes are associated with the H3 acetylation and H3K4me3 modifications, suggesting they assume a chromatin structure poised for activation.

Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping.

TLDR
High-resolution genome-wide mapping of diacetylation of histone H3 at Lys 9 and Lys 14 in resting and activated human T cells by genome- wide mapping technique (GMAT) shows that high levels of the H3 acetylation are detected in gene-rich regions.

High-resolution genome-wide mapping of histone modifications

TLDR
Using GMAT, it is found that the highest acetylation levels are detected in the 5′ end of a gene's coding region, but not in the promoter, which indicates that GMAT should find valuable applications in mapping target sites of chromatin-modifying enzymes.

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

Methylation of histone H3 Lys 4 in coding regions of active genes

TLDR
It is concluded that Set1 facilitates transcription, in part, by protecting active coding regions from deacetylation, in the context of recent studies showing that Lys 4 methylation precludes histone de acetylase recruitment.

Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns.

TLDR
This study exploits the highly conserved nature of epigenetic modifications to identify potential transcriptional enhancers and establishes a novel genome-wide method for identifying regulatory elements not discernable by comparative genomics alone.

Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast

...