High-Resolution Profiling of Histone Methylations in the Human Genome

  title={High-Resolution Profiling of Histone Methylations in the Human Genome},
  author={Artem Barski and Suresh Cuddapah and Kairong Cui and Tae-young Roh and Dustin E. Schones and Zhibin Wang and Gang W. Wei and Iouri Chepelev and Keji Zhao},
Histone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology. Typical patterns of histone methylations exhibited at promoters, insulators, enhancers, and transcribed regions are identified. The monomethylations of… CONTINUE READING
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