High-Resolution Mapping of H1 Linker Histone Variants in Embryonic Stem Cells

  title={High-Resolution Mapping of H1 Linker Histone Variants in Embryonic Stem Cells},
  author={Kaixiang Cao and Nathalie Lailler and Yunzhe Zhang and Ashwath S Kumar and Karan Uppal and Zheng Hui Liu and Eva K. Lee and Hongwei Wu and Magdalena Medrzycki and Chenyi Pan and Po-Yi Ho and Guy Paul Cooper and Xiao Dong and Christoph Bock and Eric E. Bouhassira and Yuhong Fan},
  booktitle={PLoS genetics},
H1 linker histones facilitate higher-order chromatin folding and are essential for mammalian development. To achieve high-resolution mapping of H1 variants H1d and H1c in embryonic stem cells (ESCs), we have established a knock-in system and shown that the N-terminally tagged H1 proteins are functionally interchangeable to their endogenous counterparts in vivo. H1d and H1c are depleted from GC- and gene-rich regions and active promoters, inversely correlated with H3K4me3, but positively… CONTINUE READING
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