High Resolution Genomic Profiling Using Single Nucleotide Polymorphism Microarrays Identifies Multiple Novel Genomic Lesions in Pediatric Acute Lymphoblastic Leukemia.

@inproceedings{Mullighan2006HighRG,
  title={High Resolution Genomic Profiling Using Single Nucleotide Polymorphism Microarrays Identifies Multiple Novel Genomic Lesions in Pediatric Acute Lymphoblastic Leukemia.},
  author={Charles G Mullighan and Salil Goorha and Ina Radtke and James Dalton and Jing Ma and Stanley B Pounds and Xiaoping Su and Ching-Hon Pui and Mary V. Relling and Williams E Evans and James R. Downing},
  year={2006}
}
To obtain a comprehensive registry of oncogenic lesions in pediatric acute lymphoblastic leukemia (ALL), we used Affymetrix single nucleotide polymorphism (SNP) arrays to examine changes in DNA copy number and loss-of heterozygosity (LOH) in leukemic blasts and matched remission samples from 250 ALLs. We studied B-progenitor ALLs with high hyperdiploidy, n=39; ETV6-RUNX1 , n=47; MLL rearranged, n=11; TCF3-PBX1 , n=17; BCR-ABL1 , n=9; low hyperdiploidy, n=23; hypodiploidy, n=10; unclassified… CONTINUE READING