High Resolution Discrimination of Clinical Mycobacterium tuberculosis Complex Strains Based on Single Nucleotide Polymorphisms

@inproceedings{Homolka2012HighRD,
  title={High Resolution Discrimination of Clinical Mycobacterium tuberculosis Complex Strains Based on Single Nucleotide Polymorphisms},
  author={Susanne Homolka and Michaela Projahn and Silke Feuerriegel and Tanja Ubben and Roland Diel and Ulrich Nuebel and Stefan Niemann},
  booktitle={PloS one},
  year={2012}
}
Recently, the diversity of the Mycobacterium tuberculosis complex (MTBC) population structure has been described in detail. Based on geographical separation and specific host pathogen co-evolution shaping MTBC virulence traits, at least 20 major lineages/genotypes have evolved finally leading to a clear influence of strain genetic background on transmissibility, clinical presentation/outcome, and resistance development. Therefore, high resolution genotyping for characterization of strains in… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
38 Citations
36 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Single-nucleotide polymorphism in the fadD28 gene as a genetic marker for East Asia Lineage Mycobacterium tuberculosis

  • Chuang P-C, Chen H-Y, R Jou
  • J Clin Microbiol
  • 2010
2 Excerpts

Similar Papers

Loading similar papers…