High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome

@inproceedings{Shiryaev2013HighResolutionAA,
  title={High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome},
  author={Sergey A. Shiryaev and Andrei V. Chernov and Vladislav S. Golubkov and Elliot R Thomsen and Eugene Chudin and Mark S. Chee and Igor A. Kozlov and Alex Y Strongin and Piotr Cieplak},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND There is a growing appreciation of the role of proteolytic processes in human health and disease, but tools for analysis of such processes on a proteome-wide scale are limited. Furin is a ubiquitous proprotein convertase that cleaves after basic residues and transforms secretory proproteins into biologically active proteins. Despite this important role, many furin substrates remain unknown in the human proteome. METHODOLOGY/PRINCIPAL FINDINGS We devised an approach for proteinase… CONTINUE READING
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