High Rates of Occult Fallopian Tube Cancer Diagnosed at Prophylactic Bilateral Salpingo-Oophorectomy

  title={High Rates of Occult Fallopian Tube Cancer Diagnosed at Prophylactic Bilateral Salpingo-Oophorectomy},
  author={Jane Elizabeth Hirst and Gregory B. Gard and Kirsty McIllroy and David Nevell and Michael Field},
  journal={International Journal of Gynecologic Cancer},
  pages={826-829 - 826-829}
Objective: To determine the rate of occult malignancy in patients undergoing prophylactic bilateral salpingo-oophorectomy in Northern Sydney. Methods: A retrospective case series of 45 consecutive patients who underwent prophylactic bilateral salpingo-oophorectomy between 2004 and March 2008. Results: Five (11%) cases of occult neoplasia were found in 45 patients. This included 3 cases of micro-invasive serous carcinoma of the fallopian tube, 1 case of in situ carcinoma in the fallopian tube… 

Risk-reducing Salpingo-Oophorectomy in Women at Higher Risk of Ovarian and Breast Cancer: A Single Institution Prospective Series.

The data still support the indication for RRSO in higher-risk patients, and an endometrial biopsy should also be routinely obtained as it raises the chances of detecting occultendometrial cancers that may be otherwise missed.

Pathological findings following risk-reducing salpingo-oophorectomy in BRCA mutation carriers: A systematic review and meta-analysis.

  • Aoshuang ChengLei LiMing WuJ. Lang
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  • 2019

Ovarian Cancer: The Fallopian Tube as the Site of Origin and Opportunities for Prevention

Growing evidence now supports the fallopian tube epithelia as an etiological site for the development of HGSC and consequently, salpingectomy alone is emerging as a prophylactic option.

Incidence and Characteristics of Unsuspected Neoplasia Discovered in High-Risk Women Undergoing Risk Reductive Bilateral Salpingooophorectomy

The incidence of neoplasia within a high-risk Australian population undergoing risk-reducing bilateral salpingo-oophorectomy is found to be 3.62% and all patients with STIC remained disease free.

Clinical and Pathological Characteristics of Incidental Diagnostic Early Occult Malignancy After Risk-Reducing Salpingo-Oophorectomy in BRCA Mutation Carriers

Two cases with malignant origins within the Fallopian tube, while sparing the ovaries in their entirety, support the fallopian tubes as the originating organ for some ovarian or peritoneal malignancies in BRCA mutation carriers.

Occult Tubal Carcinoma After Risk-Reducing Salpingo-oophorectomy: A Systematic Review.

Occult tubal carcinomas found at risk-reducing salpingo-oophorectomy in high-risk patients and BRCA mutation carriers have significant potential for recurrence despite the frequent administration of postoperative chemotherapy.

The Impact of Prophylactic Salpingo-oophorectomy on Health in Women who carry a BRCA1 or BRCA2 Mutation

Most women were significantly less worried about cancer after the surgery, however, a subset of women continued to experience significant cancer specific distress after prophylactic salpingo-oophorectomy, and Satisfaction with the decision to undergo prophylectomy was high regardless of these symptoms.

Pathologic findings at risk-reducing salpingo-oophorectomy: primary results from Gynecologic Oncology Group Trial GOG-0199.

BRCA1/2 mutation, postmenopausal status, and abnormal preoperative CA-125 and/or TVU examinations were associated with cancer detection at RRSO, and can inform management decisions among women at high risk of ovarian/tubal cancer.

Title Pathologic Findings at Risk-Reducing Salpingo-Oophorectomy : Primary Results From Gynecologic Oncology Group Trial GOG-0199 Permalink

BRCA1/2 mutation, postmenopausal status, and abnormal preoperative CA-125 and/or TVU were associated with cancer detection at RRSO, and these data can inform management decisions among women at high risk of ovarian/tubal cancer.



Risk-reducing salpingo-oophorectomy in BRCA mutation carriers: role of serial sectioning in the detection of occult malignancy.

A rigorous operative and pathologic protocol for RRSO increases the detection rate of occult ovarian malignancy in BRCA mutation carriers nearly seven-fold, and this finding will alter postoperative management because additional staging, chemotherapy, and follow-up may be necessary in affected women.

Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction.

  • M. CallahanC. Crum M. Muto
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2007
The distal fallopian tube seems to be the dominant site of origin for early malignancies detected in approximately 6% of women undergoing ovarian cancer risk-reduction surgery, and the greatest proportion of serous cancer risk in BRCA mutation-positive women should be assigned to the fimbria rather than the ovary.

Salpingo-Oophorectomy and the Risk Of Ovarian, Fallopian Tube, and Peritoneal Cancers in Women With a BRCA1 or BRCA2 Mutation

Oophorectomy is associated with reduced risk of ovarian and fallopian tube cancer in high-risk women, although there is a substantial residual risk for peritoneal cancer in BRCA1 and BRCa2 mutation carriers following prophylactic salpingo-oophoreCTomy.

Pathologic findings in prophylactic oophorectomy specimens in high-risk women.

The findings support the recommendations that in this high-risk population the fallopian tubes and ovaries should be submitted entirely and be evaluated by a pathologist with expertise in gynecologic malignancies in serial sections.

The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome

The fimbria was the most common location for early serous carcinoma in this series of BRCA-positive women, and Investigative strategies targeting the fimbriated end of the fallopian tube should further define its role in the pathogenesis of familial and sporadic ovarianSerous carcinomas.

Atypical Epithelial Proliferation in Fallopian Tubes in Prophylactic Salpingo-oophorectomy Specimens from BRCA1 and BRCA2 Germline Mutation Carriers

  • M. CarcangiuP. Radice B. Pasini
  • Medicine
    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • 2004
The frequency of proliferative lesions of the tubal epithelium, including in situ carcinoma, appears to be increased in BRCA1 mutation carriers, and removal and thorough examination of the fallopian tubes at the time of surgical prophylaxis for ovarian cancer is recommended.

Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations.

Bilateral prophylactic oophorectomy reduces the risk of coelomic epithelial cancer and breast cancer in women with BRCA1 or BRCa2 mutations.

Clinical outcome of prophylactic oophorectomy in BRCA1/BRCA2 mutation carriers and events during follow-up

The thesis that BRCA1 germline mutation carriers are not only at risk for ovarian cancer, but also for fallopian tube carcinoma and peritoneal papillary serous carcinoma is contributed to.