High Rate of Subclinical Chikungunya Virus Infection and Association of Neutralizing Antibody with Protection in a Prospective Cohort in The Philippines

@inproceedings{Yoon2015HighRO,
  title={High Rate of Subclinical Chikungunya Virus Infection and Association of Neutralizing Antibody with Protection in a Prospective Cohort in The Philippines},
  author={I H Yoon and Maria Theresa P. Alera and Catherine B. Lago and Ilya A. Tac-An and Daisy Villa and Stefan Fernandez and Butsaya K Thaisomboonsuk and Chonticha Klungthong and Jens W Levy and John Mark S. Velasco and Vito G. Roque and Henrik Salje and Louis R. Macareo and Laura L. Hermann and Ananda N Nisalak and Anon Srikiatkhachorn},
  booktitle={PLoS neglected tropical diseases},
  year={2015}
}
BACKGROUND Chikungunya virus (CHIKV) is a globally re-emerging arbovirus for which previous studies have indicated the majority of infections result in symptomatic febrile illness. We sought to characterize the proportion of subclinical and symptomatic CHIKV infections in a prospective cohort study in a country with known CHIKV circulation. METHODS/FINDINGS A prospective longitudinal cohort of subjects ≥6 months old underwent community-based active surveillance for acute febrile illness in… CONTINUE READING

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