High RASSF1A promoter methylation levels are predictive of poor prognosis in fine-needle aspirate washings of breast cancer lesions

@article{Martins2010HighRP,
  title={High RASSF1A promoter methylation levels are predictive of poor prognosis in fine-needle aspirate washings of breast cancer lesions},
  author={Ana Teresa Martins and Paula Monteiro and Jo{\~a}o Ramalho-Carvalho and Vera L{\'u}cia Costa and M{\'a}rio Dinis-Ribeiro and Conceiç{\~a}o Leal and Rui Henrique and Carmen Jer{\'o}nimo},
  journal={Breast Cancer Research and Treatment},
  year={2010},
  volume={129},
  pages={1-9}
}
Previously, we reported that the accuracy of cytological diagnosis of breast lesions could be augmented through the quantitative assessment of DNA methylation of fine-needle aspirate (FNA) washings. Herein, we aimed at the evaluation of the prognostic value of quantitative promoter methylation at three gene loci (APC, CCND2, and RASSF1A) in a large series of FNA washings from breast lesions. Methylation levels of three gene promoters were assessed by quantitative methylation-specific PCR in… CONTINUE READING
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