High Prevalence of Fatty Acid Synthase Expression in Colorectal Cancers in Middle Eastern Patients and Its Potential Role as a Therapeutic Target

@article{Uddin2009HighPO,
  title={High Prevalence of Fatty Acid Synthase Expression in Colorectal Cancers in Middle Eastern Patients and Its Potential Role as a Therapeutic Target},
  author={Shahab Uddin and Azhar R. Hussain and M El-Garhy Ahmed and Jehad Abubaker and Nasser A. Al-Sanea and Alaa Abduljabbar and Luai H. S. Ashari and Samar J Alhomoud and Fouad Hassan Al-Dayel and Prashant Bavi and Khawla S Al-Kuraya},
  journal={The American Journal of Gastroenterology},
  year={2009},
  volume={104},
  pages={1790-1801}
}
OBJECTIVES:Many human epithelial cancers, particularly those with a poor prognosis, express high levels of fatty acid synthase (FASN), a key metabolic enzyme linked to synthesis of membrane phospholipids in cancer cells. Overexpression of FASN is linked with activation of the phosphatidylinositol-3′-kinase (PI3 K)/AKT pathway. However, the role of FASN in colorectal cancer (CRC) has not been fully elucidated. We investigated the expression of FASN and determined its functional association with… CONTINUE READING
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