High Prevalence of Drug Resistance Mutations Among Patients Failing First-Line Antiretroviral Therapy and Predictors of Virological Response 24 Weeks After Switch to Second-Line Therapy in São Paulo State, Brazil.

@article{Matsuda2017HighPO,
  title={High Prevalence of Drug Resistance Mutations Among Patients Failing First-Line Antiretroviral Therapy and Predictors of Virological Response 24 Weeks After Switch to Second-Line Therapy in S{\~a}o Paulo State, Brazil.},
  author={Elaine Monteiro Matsuda and Luana Portes Oz{\'o}rio Coelho and Giselle de Faria Romero and M{\^o}nica Jacques de Moraes and Giselle Ibete Silva Lopez-Lopes and Karen Mirna Loro Morej{\'o}n and Alexandre Ely Camp{\'e}as and Gabriela Bastos Cabral and Lu{\'i}s Fernando Br{\'i}gido},
  journal={AIDS research and human retroviruses},
  year={2017}
}
Universal antiretroviral treatment with sustained viral suppression benefits patients and reduces HIV transmission. Effectiveness of therapy may be limited by antiretroviral drug resistance. Information on the resistance profile at treatment failure and its impact on antiretroviral drugs may subsidize subsequent treatment strategies. Partial pol sequences from 319 patients failing first-line therapy were analyzed for resistance associated mutations (RAMs) and HIV subtype. Demographic data, CD4… CONTINUE READING