High-Precision Radiosurgical Dose Delivery by Interlaced Microbeam Arrays of High-Flux Low-Energy Synchrotron X-Rays

@inproceedings{Serduc2010HighPrecisionRD,
  title={High-Precision Radiosurgical Dose Delivery by Interlaced Microbeam Arrays of High-Flux Low-Energy Synchrotron X-Rays},
  author={Raph{\"a}el Serduc and Elke Br{\"a}uer-Krisch and Erik Albert Siegbahn and Audrey Bouchet and Beno{\^i}t Pouyatos and Romain Carron and N. A. Pannetier and Luc Renaud and Gilles Berruyer and Christian Nemoz and Thierry Brochard and Chantal R{\'e}my and Emmanuel Luc Barbier and Alberto Bravin and G{\'e}raldine Le Duc and Antoine Depaulis and François Est{\`e}ve and Jean Albert Laissue},
  booktitle={PloS one},
  year={2010}
}
Microbeam Radiation Therapy (MRT) is a preclinical form of radiosurgery dedicated to brain tumor treatment. It uses micrometer-wide synchrotron-generated X-ray beams on the basis of spatial beam fractionation. Due to the radioresistance of normal brain vasculature to MRT, a continuous blood supply can be maintained which would in part explain the surprising tolerance of normal tissues to very high radiation doses (hundreds of Gy). Based on this well described normal tissue sparing effect of… CONTINUE READING

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