High Plasma Norepinephrine Levels Associated with β2-Adrenoceptor Polymorphisms Predict Future Renal Damage in Nonobese Normotensive Individuals

@article{Masuo2007HighPN,
  title={High Plasma Norepinephrine Levels Associated with β2-Adrenoceptor Polymorphisms Predict Future Renal Damage in Nonobese Normotensive Individuals},
  author={Kazuko Masuo and Tomohiro Katsuya and Ken Sugimoto and Hideki Kawaguchi and Hiromi Rakugi and Toshio Ogihara and Michael L. Tuck},
  journal={Hypertension Research},
  year={2007},
  volume={30},
  pages={503-511}
}
Renal injury is common in obesity and hypertension. In the present study, we examined relationships between renal function alterations, plasma norepinephrine (NE), and β2-adrenoceptor polymorphisms in a longitudinal design over 5 years. In 219 nonobese, normotensive men with entry-normal renal function, we measured serum blood urea nitrogen (BUN), creatinine, creatinine clearance, plasma NE, homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI), total body fat mass… CONTINUE READING