High-PerformanceLiquid-ChromatographicSimultaneous Determinationof CommonlyUsedTricyclicAntidepressants

  title={High-PerformanceLiquid-ChromatographicSimultaneous Determinationof CommonlyUsedTricyclicAntidepressants},
  author={F Henning and Herman J. Lohmann and Daniel G. Miles},
We report a method for simultaneous measurement of five commonly used tricyclic antidepressant drugs (doxepin, desipramine, nortriptyline, imipramine, and amitriptyline) in serum by paired-ion high-performance liquid chromatography, with use of a reversed-phase column and ultraviolet detection at 254 nm. The drugs are extracted from 2 ml of serum at pH 14 into hexane/isoamyl alcohol (99/1 by vol) and re-extracted into 200 Ml of 0.1 mol/liter HCI. An aliquot of the aqueous acid phase is… CONTINUE READING
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