High Performance of Histidine-Rich Protein 2 Based Rapid Diagnostic Tests in French Guiana are Explained by the Absence of pfhrp2 Gene Deletion in P. falciparum

@inproceedings{Trouvay2013HighPO,
  title={High Performance of Histidine-Rich Protein 2 Based Rapid Diagnostic Tests in French Guiana are Explained by the Absence of pfhrp2 Gene Deletion in P. falciparum},
  author={M{\'e}lanie Trouvay and Georges Palazon and Franck Berger and B{\'e}atrice Volney and Denis Blanchet and Emilie Faway and Damien Donato and Eric Legrand and Bernard Carme and Lise Musset},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Care for malaria patients in endemic areas has been improved through the increasing use of Rapid Diagnostic Tests (RDTs). Most RDTs target the histidine-rich protein-2 antigen (PfHRP2) to detect P. falciparum, as it is abundant and shows great heat stability. However, their use in South America has been widely questioned following a recent publication that pinpoints the high prevalence of Peruvian field isolates lacking the gene encoding this protein. In the remote rural health… CONTINUE READING

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