High-Performance Liquid Chromatography (HPLC) Quantification of Liposome-Delivered Doxorubicin in Arthritic Joints of Collagen-Induced Arthritis Rats

@inproceedings{Niu2017HighPerformanceLC,
  title={High-Performance Liquid Chromatography (HPLC) Quantification of Liposome-Delivered Doxorubicin in Arthritic Joints of Collagen-Induced Arthritis Rats},
  author={Hongqing Niu and Menghua Xu and Shuangtian Li and Junwei Chen and Jing Luo and Xiangcong Zhao and Chong Shou Gao and Xiaofeng Li},
  booktitle={Medical science monitor basic research},
  year={2017}
}
BACKGROUND Neoangiogenesis occurring in inflamed articular synovium in early rheumatoid arthritis (RA) is characterized by enhanced vascular permeability that allows nanoparticle agents, including liposomes, to deliver encapsulated drugs to arthritic joints and subsequently improve therapeutic efficacy and reduce adverse effects. However, the targeting distribution of liposomes in arthritic joints during RA has not been quantitatively demonstrated. We performed this study to evaluate the… CONTINUE READING