High-Performance Liquid Chromatographic Analysis of Tocainide in Human Plasma

A method for the determination of tocainide, a new antiarrhythmic drug, by means of ion-pair High Performance Liquid Chromatography (HPLC), is described. The drug and its chemically related internal standard are extracted from the basified plasma sample with methylene chloride. The organic extract is evaporated to dryness, dissolved in the mobile phase and… (More)