High-Performance Liquid Chromatographic (HPLC) Analysis of Oligomeric Components of the Spermicide Nonoxynol-9

Abstract

The commercially available Nonoxynol-9 spermicide is a multicomponent mixture of oligomers. When Nonoxynol-9 was separated by normal phase gradient HPLC, 17 components were shown to exist in the commercial mixture. These oligomeric components follow a Poisson distribution around the most abundant oligomer, EO 8 (11.7%). Select oligomers were isolated by… (More)
DOI: 10.1023/A:1015870304964

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