High-Performance Capillary Electrophoresis for Determining HIV-1 Tat Protein in Neurons

  title={High-Performance Capillary Electrophoresis for Determining HIV-1 Tat Protein in Neurons},
  author={Satish L. Deshmane and Ruma Mukerjee and Shongshan Fan and Bassel E. Sawaya},
  booktitle={PloS one},
The HIV-1 protein, Tat has been implicated in AIDS pathogenesis however, the amount of circulating Tat is believed to be very low and its quantification has been difficult. We performed the quantification of Tat released from infected cells and taken up by neurons using high performance capillary electrophoresis. This is the first report to successfully measure the amount of Tat in neurons and places Tat as a key player involved in HIV-associated neurocognitive disorders. 
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Tubulinmediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal-dependent degradation of microtubule-associated protein 2 and neuronal damage

  • S Aprea, L Del Valle, G Mameli, BE Sawaya, K Khalili
  • J Neurosci
  • 2006
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