High Occupancy of Sigma-1 Receptors in the Human Brain after Single Oral Administration of Fluvoxamine: A Positron Emission Tomography Study Using [11C]SA4503

@article{Ishikawa2007HighOO,
  title={High Occupancy of Sigma-1 Receptors in the Human Brain after Single Oral Administration of Fluvoxamine: A Positron Emission Tomography Study Using [11C]SA4503},
  author={M. Ishikawa and K. Ishiwata and K. Ishii and Y. Kimura and K. Hashimoto},
  journal={Biological Psychiatry},
  year={2007},
  volume={62},
  pages={878-883}
}
  • M. Ishikawa, K. Ishiwata, +2 authors K. Hashimoto
  • Published 2007
  • Medicine, Psychology
  • Biological Psychiatry
  • BACKGROUND Sigma-1 receptors might be implicated in the pathophysiology of psychiatric diseases, as well as in the mechanisms of action of some selective serotonin reuptake inhibitors (SSRIs). Among the several SSRIs, fluvoxamine has the highest affinity for sigma-1 receptors (Ki = 36 nM), whereas paroxetine shows low affinity (Ki = 1893 nM). The present study was undertaken to examine whether fluvoxamine binds to sigma-1 receptors in living human brain. METHODS A dynamic positron emission… CONTINUE READING
    Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands
    • 274
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 48 REFERENCES
    σ-1 Receptor Ligands
    • 223