High-Novelty-Preference Rats are Predisposed to Compulsive Cocaine Self-administration

  title={High-Novelty-Preference Rats are Predisposed to Compulsive Cocaine Self-administration},
  author={David Belin and Nad{\`e}ge Berson and Eric Balado and Pier Vincenzo Vincenzo Piazza and V{\'e}ronique Deroche-Gamonet},
Sensation/novelty-seeking is amongst the best markers of cocaine addiction in humans. However, its implication in the vulnerability to cocaine addiction is still a matter of debate, as it is unclear whether this trait precedes or follows the development of addiction. Sensation/novelty-seeking trait has been identified in rats on the basis of either novelty-induced locomotor activity (high-responder (HR) trait) or novelty-induced place preference (high-novelty-preference trait (HNP)). HR and HNP… CONTINUE READING
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