High Neonatal Leptin Exposure Enhances Brain GR Expression and Feedback Efficacy on the Adrenocortical Axis of Developing Rats.

@article{Proulx2001HighNL,
  title={High Neonatal Leptin Exposure Enhances Brain GR Expression and Feedback Efficacy on the Adrenocortical Axis of Developing Rats.},
  author={Karine Proulx and Se Bastien Clavel and Genevie Ve Nault and D. Carr Richard and Claire-Dominique Walker},
  journal={Endocrinology},
  year={2001},
  volume={142 11},
  pages={4607-4616}
}
Leptin modifies the activity of the hypothalamic-pituitary-adrenal axis in adult rodents and inhibits the production of glucocorticoids from human and rat adrenals in vitro. During development, high levels of circulating leptin and low levels of corticosterone secretion are observed together with adrenal hyporesponsiveness to stress. As chronic neonatal leptin administration reduced stress-induced corticotropin-releasing factor mRNA expression and ACTH secretion in pups, we determined whether… CONTINUE READING

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