High Mobility Group Box 1: a potential therapeutic target for systemic lupus erythematosus

@article{Pan2009HighMG,
  title={High Mobility Group Box 1: a potential therapeutic target for systemic lupus erythematosus},
  author={Hai-Feng Pan and Guo-Cui Wu and Weiping Li and Xiang-Pei Li and Dongqing Ye},
  journal={Molecular Biology Reports},
  year={2009},
  volume={37},
  pages={1191-1195}
}
High Mobility Group Box 1 (HMGB1) is a nuclear protein participating in chromatin architecture and transcriptional regulation. Recently, there is increasing evidence that HMGB1 contributes to the pathogenesis of chronic inflammatory and autoimmune diseases due to its pro-inflammatory and immunostimulatory properties. Elevated expression of HMGB1 was found in the sera of patients and mice with systemic lupus erythematosus (SLE). In addition, it has been shown that HMGB1 may act as a… 

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