High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells.

@article{Tawiah2018HighMM,
  title={High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells.},
  author={Adelaide Tawiah and Steve Cornick and France Moreau and Hayley Gorman and Manish Kumar and Sameer Tiwari and Kris Chadee},
  journal={The American journal of pathology},
  year={2018},
  volume={188 6},
  pages={
          1354-1373
        }
}
MUC2 mucin is a large glycoprotein produced by goblet cells that forms the protective mucus blanket overlying the intestinal epithelium as the first line of innate host defense. High MUC2 production in inflammatory bowel disease and infectious colitis depletes goblet cells and the mucus layer by an unknown mechanism. Herein, we analyzed the effect of high MUC2 biosynthesis on endoplasmic reticulum (ER) stress and apoptosis in goblet cells using a high MUC2-producing human goblet cell line (HT29… CONTINUE READING
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