High Levels of Soluble Lectinlike Oxidized Low‐Density Lipoprotein Receptor‐1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke

@article{Markstad2019HighLO,
  title={High Levels of Soluble Lectinlike Oxidized Low‐Density Lipoprotein Receptor‐1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke},
  author={Hanna Markstad and A. Edsfeldt and Ingrid Yao Mattison and E. Bengtsson and Pratibha Singh and M. Cavalera and G. Asciutto and H. Bj{\"o}rkbacka and G. Fredrikson and N. Dias and P. Volkov and M. Orho-Melander and J. Nilsson and G. Engstr{\"o}m and I. Gonçalves},
  journal={Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease},
  year={2019},
  volume={8}
}
  • Hanna Markstad, A. Edsfeldt, +12 authors I. Gonçalves
  • Published 2019
  • Medicine
  • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
  • Background When the lectinlike oxidized low‐density lipoprotein (oxLDL) receptor‐1 (LOX‐1), a scavenger receptor for oxLDL, binds oxLDL, processes leading to endothelial dysfunction and inflammation are promoted. We aimed to study release mechanisms of LOX‐1 and how circulating levels of soluble LOX‐1 (sLOX‐1) relate to plaque inflammation and future risk for ischemic stroke. Methods and Results Endothelial cells and leukocytes were used to study release of sLOX‐1. Plasma levels of sLOX‐1 were… CONTINUE READING
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